Chromogenic substrates of sialidase and methods of making and using the same
US6512100B1 · kind B1 · utility
4Cited by
4References
21Claims
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Key dates
| Filing date | Aug 30, 2000 |
| Grant date | Jan 28, 2003 |
| Priority date | — |
| Expiry date | Sep 1, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/075
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.