Process for the preparation of bicyclic compounds and the use of this process for the preparation of an ice inhibitor compound
US6512111B1 · kind B1 · utility
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13Claims
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Key dates
| Filing date | Jul 27, 2001 |
| Grant date | Jan 28, 2003 |
| Priority date | — |
| Expiry date | Jul 27, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06139
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for preparing compounds of formula (I) wherein R is selected from the group consisting of H. alkyl, aryl, and aralkyl of up to 18 carbon atoms and the amine function may be free or protected from a compound of formula (IA) wherein cyclization is carried out in a basic medium and in the presence of a phosphonic acid derivative and the use of said method as an intermediate step for preparing a compound inhibiting the interleukin-1 beta conversion enzyme.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.