Methods for forming regional tissue adherent barriers and drug delivery systems
US6514534B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 14, 1998 |
| Grant date | Feb 4, 2003 |
| Priority date | — |
| Expiry date | Aug 14, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of time, and may be formed by free radical polymerization initiated by a redox system or thermal initiation, or electrophilic-nucleophilic mechanism, wherein two components of an initiating system are simultaneously or sequentially poured into a body cavity to obtain widespread dispersal and coating of all or most visceral organs within that cavity prior to gelation and polymerization of the regional barrier. The hydrogel materials are selected to have a low stress at break in tension or torsion, and so as to have a close to equilibrium hydration level when formed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.