Method of using cyclic peptides to inhibit binding to urokinase-type plasminogen activator receptor
US6514710B1 · kind B1 · utility
10Cited by
1References
12Claims
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Key dates
| Filing date | Apr 5, 1999 |
| Grant date | Feb 4, 2003 |
| Priority date | — |
| Expiry date | Apr 5, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cyclic peptide compounds having 11 amino acids joined by a linking unit L, such that the linear dimension between the C&agr; carbon of the first amino acid and the C&agr; carbon of eleventh amino acid is between about 4 and 12 ångstrom units; are useful for inhibiting the binding of uPA to the uPAR receptor. Methods for using the cyclic peptide compounds, and compositions containing them, for inhibiting the growth or metastasis of cancerous tumors are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.