Oncoprotein protein kinase

US6514745B1 · kind B1 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Michael Karin · Village of La Jolla, US
• Masahiko Hibi · San Diego, US
• Anning Lin · Village of La Jolla, US
• Roger J. Davis · Princeton, US
• Benoit Derijard · Nice, FR

Key dates

• Filing date: Mar 25, 1994
• Grant date: Feb 4, 2003
• Expiry date: Mar 25, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An isolated polypeptide (JNK) characterized by having a molecular weight of 46kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.