Replicable probe array
US6514768B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 29, 1999 |
| Grant date | Feb 4, 2003 |
| Priority date | — |
| Expiry date | Jan 29, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/849
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A system for producing substantially identical specific binding ligand (e.g., nucleic acid) probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address sequences immobilized in the form of a patterned, and optionally random, array, b) a multi-ligand conjugate having a binding domain complementary to an address sequence, a binding domain complementary to a target sequence, and a third ligand for use in forming (e.g., by binding or polymerization) the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary sequences.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.