Frangible compounds for pathogen inactivation

US6514987B1 · kind B1 · utility

Assignee

• Cerus Corporation · US

Inventors

• David N. Cook · Lafayette, US
• John E. Merritt · Walnut Creek, US
• Aileen Nerio · Fremont, US
• Henry Rapoport · Berkeley, US
• Adonis Stassinopoulos · Dublin, US
• Susan Wollowitz · Walnut Creek, US
• Jan Matejovic · Toronto, CA
• William Alexander Denny · Beachlands, NZ

Key dates

• Filing date: Jul 2, 2000
• Grant date: Feb 4, 2003
• Expiry date: Sep 29, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/64
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell preparations and plasma. The compounds and methods may be used to treat materials intended for in vitro or in vivo use, such as clinical testing or transfusion. The compounds are designed to specifically bind to and react with nucleic acid, and then to degrade to form breakdown products. The degradation reaction is preferably slower than the reaction with nucleic acid.