Compounds and compositions for treating C1s-mediated diseases and conditions

US6515002B2 · kind B2 · utility

Assignee

• 3-Dimensional Pharmaceuticals, Inc. · US

Inventors

• Carl R. Illig · Phoenixville, US
• Nalin Subasinghe · Exton, US
• James B. Hoffman · Ardmore, US
• Kenneth Wilson · Puntarenas, CR
• M. Jonathan Rudolph · Doylestown, US
• Roger F. Bone · Bound Brook, US
• Scott L. Klein · Norristown, US
• Troy L. Randle · Lindenwold, US

Key dates

• Filing date: Sep 26, 2001
• Grant date: Feb 4, 2003
• Expiry date: Sep 26, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4, X, Y and Z are defined in the specification.