Thrombin inhibitors

US6515011B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Harold G. Selnick · Ambler, US
• James C. Barrow · Harleysville, US
• Philippe G. Nantermet · Lansdale, US
• Peter D. Williams · Harleysville, US
• Kenneth J. Stauffer · Pottstown, US
• Philip E. Sanderson · Philadelphia, US
• Kenneth E. Rittle · Lansdale, US
• Matthew Morrissette · Las Vegas, US
• Catherine M. Wiscount · Allentown, US
• Lekhanh O. Tran · West Chester, US
• Terry A. Lyle · Lederach, US
• Donnette D. Staas · Harleysville, US

Key dates

• Filing date: Dec 18, 2001
• Grant date: Feb 4, 2003
• Expiry date: Dec 18, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e.g. where R3 is —CH2NH2, —CH2CH2NH2, or —CH2NHC(O)OC(CH3)3.