Method for the preparation of novel sidechain-bearing taxanes and intermediates thereof
US6515151B1 · kind B1 · utility
4Cited by
43References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 13, 2000 |
| Grant date | Feb 4, 2003 |
| Priority date | — |
| Expiry date | Jun 13, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Compounds prepared by the methods of the present invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.