Patent · US Expired

Decorin binding protein essential peptides and methods of use

US6517838B1 · kind B1 · utility

12Cited by

1References

3Claims

0Family size

Assignee

THE TEXAS A&M UNIVERSITY SYSTEM · US

Inventors

Magnus A. H{umlaut over (oo)}k · Houston, US
Eric Brown · Bellaire, US

Key dates

Filing date	Jun 16, 2000
Grant date	Feb 11, 2003
Priority date	—
Expiry date	Nov 22, 2020

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Borrelia burgdorferi, the causative agent of Lyme disease, expresses on its surface a decorin binding protein, DbpA and DbpB. Lysine residues necessary for DbpA binding to decorin and DbpA peptides containing these critical residues essential for decorin binding are disclosed. It is further disclosed that vaccination using peptides incorporating these critical binding domains of DbpA can confer a delayed-type hypersensitivity response to DbpA and reduce the number of B. burgdorferi organisms present in infected animals.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.