Methods for inducing interleukin-12 and a type1/Th1 T-cell response

US6517839B1 · kind B1 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Robert L. Modlin · McNeil, US
• Daniel H. Libraty · Bangkok, TH

Key dates

• Filing date: Jul 17, 1998
• Grant date: Feb 11, 2003
• Expiry date: Jul 17, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/57
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for inducing interleukin-12 production and inducing a type 1/Th1 T cell response in a subject, thereby stimulating cell-mediated immunity for prevention or treatment of pathogen infections or treatment of a interferon (-sensitive tumor, are provided. Compounds effective in the above-described methods include a lipopeptide having an N-terminal ester- or amide-linked fatty acyl group and are administered in an amount effective to induce interleukin-12 and to induce the type 1/Th1 T-cell response. Preferably, the subject is a human patient, and the lipopeptide is an N-terminal moiety of a 19 kDa or a 38 kDa lipoprotein of Mycobacterium tuberculosis.