Automated chemical synthesis apparatus

US6518067B1 · kind B1 · utility

Assignees

• Gesellschaft fur Biotechnologische Forschung mbH (GBF) · DE
• Abimed Analysen-Technik GmbH · DE
• IMB Institut Fuer Molekulare Biotechnologie E.V. · DE

Inventors

• Ronald Frank · Calgary, CA
• Stefan Matysiak · Braunschweig, DE
• Olaf Schreuer · Braunschweig, DE
• Heinrich Gausepohl
• Andre Rosenthal · Jena, DE

Key dates

• Filing date: Nov 30, 1999
• Grant date: Feb 11, 2003
• Expiry date: Nov 30, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B60/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The disclosed synthesis system is based on the idea of designing a synthesis and treatment procedure, substrates and anchor groups which enable biomolecules to be simultaneously produced in an entirely automatic manner. By using a pipetting robot to dispense the reagents, the reaction column can be arranged in a format suitable for subsequent treatment. For a pipetting robot to carry out even water-sensitive or air-sensitive synthesis protocols, certain structural measures must be taken. The operation principle of the automated and the synthesis sequence are described below as an example of a possible solution. The automation can work with conventional substrates and reagents. Handling, however, is simplified by new, specially adapted substrates and anchor groups. A special, simultaneous purification and aliquot portioning process improves product quality and makes the device easier to use.