Patent · US Expired

Desleucyl glycopeptide antibiotics and methods of making same

US6518243B1 · kind B1 · utility

25Cited by
4References
40Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMar 31, 2000
Grant dateFeb 11, 2003
Priority date—
Expiry dateMar 31, 2020

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K38/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Compounds that are analogs of glycopeptide antibiotics are disclosed. The compounds have the formula A1-A2-A3-A4-A5-A6-A7 wherein each of the groups A2 to A7 is a modified or unmodified &agr;-amino acid residue, A1 is optional and, when present, is an organic group other than N-substituted leucine, and at least one of the groups A1 to A7 is linked via a glycosidic bond to one or more glycosidic groups each having one or more sugar residues, wherein at least one of said sugar residues is modified to bear at least one hydrophobic substituent. Methods of making these compounds, compositions including these compounds, and methods of using the compounds to treat infections in a host are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.