Squaric acid derivatives
US6518283B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 25, 2000 |
| Grant date | Feb 11, 2003 |
| Priority date | — |
| Expiry date | May 25, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Squaric acid Derivatives of formula (1) are described: whereinR1 is an integrin binding group;R2 is a hydrogen atom or a C1-6alkyl group;L1 is a covalent bond or a linker atom or group;n is zero or the integer 1;Alk1 is an optionally substituted aliphatic chain;R3 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group: and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune of inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.