Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases

US6518305B1 · kind B1 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Clarence J. Maring · Libertyville, US
• Yuanwei Chen · Sichuan, CN
• David A. DeGoey · Salem, US
• Vincent L. Giranda · Gurnee, US
• David J. Grampovnik · Waukegan, US
• Yu Gui Gu · Acton, US
• Warren M. Kati · Gurnee, US
• Dale J. Kempf · Libertyville, US
• April L. Kennedy · Denver, US
• Allan C. Krueger · Gurnee, US
• Zhen Lin · Gurnee, US
• Darold L. Madigan · Elk Grove Village, US
• Steven W. Muchmore · Libertyville, US
• Hing L. Sham · South San Francisco, US
• Kent D. Stewart · Gurnee, US
• Vincent S. Stoll · Libertyville, US
• Minghua Sun · Libertyville, US
• Gary T. Wang · Libertyville, US
• Sheldon Wang · Carmel, US
• Ming C. Yeung · Grayslake, US
• Chen Zhao · Gurnee, US

Key dates

• Filing date: Oct 19, 1999
• Grant date: Feb 11, 2003
• Expiry date: Oct 19, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.