Immune enhancement

US6518312B2 · kind B2 · utility

Assignee

• Active Biotech AB · SE

Inventors

• Anders Bjork · Bjärred, SE
• Gunnar Hedlund · Lund, SE
• Tomas Leanderson · Lund, SE

Key dates

• Filing date: Jul 3, 2001
• Grant date: Feb 11, 2003
• Expiry date: Jul 3, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/535
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for stimulation of transcription factor AP (activator protein)-1 by administering a compound of the formula (I) whereinR is selected from methyl, ethyl, n-propyl, iso-propyl, c-propyl, n-butyl, sec.-butyl, iso-butyl, tert.-butyl, c-butyl, n-pentyl, sec.-pentyl, iso-pentyl, tert.-pentyl, neo-pentyl, c-pentyl, c-hexyl and c-heptyl; RNa and RNb are the same or different and selected from hydrogen, methyl and ethyl; R2, R3, R5 and R6 are independently selected from hydrogen, methyl, methoxy, thiomethyl, hydroxy, fluoro, chloro, bromo, trifluoromethyl, phenyl and benzyl;n is 1, 2 or 3;R′ and R″ are the same or different and selected from methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec.-butyl, and iso-butyl or R′ and R″ together form a saturated heterocyclic ring of 5-7 atoms; and pharmaceutically acceptable salts, hydrates and solvates thereof, to a mammal in need thereof.