Substituted pyrimidine compositions and methods of use
US6518424B1 · kind B1 · utility
1Cited by
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18Claims
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Key dates
| Filing date | Nov 10, 1999 |
| Grant date | Feb 11, 2003 |
| Priority date | — |
| Expiry date | Nov 10, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Substituted pyrimidines that have the general structure: in which the symbol R1 represents a C1-C6 alkyl, C1-C6 alkoxy or halogen atom; R2 represents a phenyl group, substituted phenyl group, benzyl moiety, substituted benzyl moiety, C3-C7 cycloalkyl, or substituted C3-C7 cycloalkyl; R3 represents a hydrogen or C1-C6 alkyl group, R4 represents —H, —OH, —N3 or —NHCOCH3; and R5 represents H are provided. These compounds have activity as inhibitors of phospholipase A2, and are useful in treating disorders mediated by phospholipase A2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.