Optical projection imaging system and method for automatically detecting cells having nuclear and cytoplasmic densitometric features associated with disease
US6519355B2 · kind B2 · utility
Inventor
Key dates
| Filing date | Jan 22, 2002 |
| Grant date | Feb 11, 2003 |
| Priority date | — |
| Expiry date | Jan 22, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30024
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system and method for rapidly detecting cells of interest using multi-dimensional, highly quantitative, nuclear and cytoplasmic densitometric features (NDFs and CDFs) includes a flow optical tomography (FOT) instrument capable of generating various optical projection images (or shadowgrams) containing accurate density information from a cell, a computer and software to analyze and reconstruct the projection images into a multi-dimensional data set, and automated feature collection and object classifiers. The system and method are particularly useful in the early detection of cancers such as lung cancer using a bronchial specimen from sputum or cheek scrapings and cervical/ovarian cancer using a cervical scraping, and the system can be used to detect rare cells in specimens including blood.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.