Permeation cell for in vitro determination of skin permeation of pharmaceutical drugs

US6521191B1 · kind B1 · utility

Assignee

• Novosis AG · DE

Inventors

• Dirk Schenk · Dietramszell, DE
• German Gassner · Friedberg, DE

Key dates

• Filing date: Jul 6, 2000
• Grant date: Feb 18, 2003
• Expiry date: Sep 21, 2020

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2013/006
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A permeation cell for the in vitro determination of the permeation of pharmaceutical active ingredients through the skin, having a donor chamber (34) and an acceptor chamber (4) that is separable therefrom, a window lying between them for receiving sealingly a skin membrane and sealingly closable filling and emptying openings at both chambers, characterized in that the acceptor chamber (4) is in the form of a cylindrical vessel that is upright during operation, having a closure (8; 50; 80) at its upper end and a side window opening (6) in the region near its base, and the donor chamber (34) is in the form of a connection piece that joins onto the acceptor chamber radially and can be closed at its outer end, with the exception of its closure (8; 50; 80) the acceptor chamber (4) is inserted removably into a housing (10) that fits closely around it, which housing has, in the region of the window opening (6) of the acceptor chamber, a corresponding slightly wider opening (30), and the connection piece forming the donor chamber (34) is screwed removably onto the housing concentrically with the window opening (6). As a result, the permeation cell gains stability, it is as easy to manipul…