Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue
US6521403B1 · kind B1 · utility
2Cited by
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8Claims
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Key dates
| Filing date | Aug 24, 2000 |
| Grant date | Feb 18, 2003 |
| Priority date | — |
| Expiry date | Aug 24, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/24222
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Antibodies to two new epitopes on the HCV envelope proteins we, identified which allow routine detection of native HCV envelope antigens, in tissue or cells derived from the host. The new epitopes are: the E1 region aa 307-326 and the N-terminal hyper variable region of E2 aa 395-415. Surprisingly, we characterised an antibody that reacts with various sequences of the hypervariable domain of E2. Specific monoclonal antibodies directed against these epitopes and allowing routine detection of viral antigen are described.
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