Nucleic acids encoding aggrecan degrading metallo proteases
US6521436B1 · kind B1 · utility
2Cited by
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4Claims
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Key dates
| Filing date | Aug 9, 2000 |
| Grant date | Feb 18, 2003 |
| Priority date | — |
| Expiry date | Dec 27, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/102
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu373-Ala374. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.