Dibenzoazulene derivatives for treating thrombosis, osteoporosis, arteriosclerosis

US6521646B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Wolfgang Stahle · Ingelheim am Rhein, DE
• Rudolf Gottschlich · Reinheim, DE
• Simon Goodman

Key dates

• Filing date: Oct 15, 2001
• Grant date: Feb 18, 2003
• Expiry date: Oct 15, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I) and their physiologically acceptable salts and solvates are useful as integrin-inhibiting substances. They are especially useful in the prophylaxis and treatment of cardiovascular disorders, of thrombosis, cardiac infarction, coronary heart diseases, arteriosclerosis, osteoporosis, in pathological conditions that are caused or propagated by angiogenesis and in tumor therapy.