Thio-oxindole derivatives

US6521657B2 · kind B2 · utility

Assignees

• Wyeth, LLC · US
• Ligand Pharmaceuticals Incorporated · US

Inventors

• Andrew Fensome · Wayne, US
• Puwen Zhang · Audubon, US
• Marci C. Koko · Wayne, US
• Lin Zhi · San Diego, US
• Todd K. Jones · Solana Beach, US
• Jay E. Wrobel · Lawrenceville, US
• Christopher M. Tegley · Thousand Oaks, US
• James P. Edwards · San Diego, US
• Edward George Melenski · Woodlyn, US

Key dates

• Filing date: Oct 30, 2001
• Grant date: Feb 18, 2003
• Expiry date: Oct 30, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds which are agonists of the progesterone receptor which have the general structure: wherein:R1, R2, R3, R4, R5 and Q1 are as defined herein, or a pharmaceutically acceptable salt thereof, as well as methods of using these compounds to induce contraception or treat progesterone-related carcinomas and adenocarcinomas.