Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
US6524554B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 2, 1999 |
| Grant date | Feb 25, 2003 |
| Priority date | — |
| Expiry date | Apr 2, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel radiopharmaceuticals comprising one to three pentapeptides, X1X2X3X4X5, independently attached to a metal chelator or bonding moiety, Ch, to which is attached a Tc-99m, Re-186, or Re-188, optionally further comprising a linking group, Ln, between-the peptides and the chelator or bonding moiety. The pentapeptide sequence binds to the tuftsin receptor and is attached at the N-terminus to Ln or Ch. These radiopharmaceuticals are useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.