Formulations and methods for providing prolonged local anesthesia

US6524607B1 · kind B1 · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• Paul Goldenheim · Wilson, US
• Mark Chasin · Manalapan, US
• Richard Sackler · Greenwich, US
• Ronald M. Burch · Wilton, US
• Joseph Tigner · New Milford, US

Key dates

• Filing date: Mar 10, 2000
• Grant date: Feb 25, 2003
• Expiry date: Mar 10, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/0024
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.