Enzyme inhibition immunoassay

US6524808B1 · kind B1 · utility

Assignee

• Roche Diagnostics GMBH · DE

Inventors

• Allan Dorn · Carmel, US
• Salvatore J. Salamone · Stockton, US
• Mitali Ghoshal · Noblesville, US
• Eva Hoess · Starnberg, DE
• Erasmus Huber · Garching bei München, DE
• Ronald Charles Hawley · Oakland, US
• John W. Patterson · Maple Valley, US

Key dates

• Filing date: Jun 26, 2000
• Grant date: Feb 25, 2003
• Expiry date: Jun 26, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/975
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.