Patent · US Expired

Process for preparing optically active 1-amino-4-(hydroxymethyl) cyclopent-2-ene derivatives

US6524844B2 · kind B2 · utility

0Cited by
3References
7Claims
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Assignee

Inventors

Key dates

Filing dateJun 22, 2001
Grant dateFeb 25, 2003
Priority date—
Expiry dateJun 22, 2021

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12P13/02
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The invention discloses a new method for producing enantiomer-enriched 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives of the general formulae (I) and (II) in which R1 is hydrogen or a possibly substituted C1-8 alkyl radical, aryl radical or cycloalkyl radical and R2 is acyl. According to said method a racemic 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivative of general formula (III), in which R1 has the meaning given above, is converted using a hydrolase and in the presence of an acylation agent

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.