Blood coagulation analyzer
US6524861B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 22, 1999 |
| Grant date | Feb 25, 2003 |
| Priority date | — |
| Expiry date | Jan 22, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/12
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
One method and apparatus for analyzing clotting characteristics of a blood sample includes the use of a non-linear equation having coefficients capable of being related to the underlying clotting processes. The non-linear equation is curve fit to a waveform of a clotting sample to provide values for the coefficients of the non-linear function. Once the coefficients are obtained, an inference engine may be used to evaluate the non-linear relationship between the coefficients and factor concentrations within the blood sample. Advantageously, the waveform of the actual sample may be detrended to extract a residual oscillatory component to aid in the determination of initial coefficients for simplifying the curve fit operation. The non-linear equation may additionally be used for providing simulated clotting waveforms for testing clot analysis instruments. A residual oscillatory component may advantageously be extracted from the clotting signal. The oscillatory components may be used to provide a high quality clot time indicator for the sample. In addition, the oscillatory component may be used to correct for clot anomalies by correlating the frequency of the oscillatory to various phy…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.