Succinoylamino carbocycles and heterocycles as inhibitors of a-&bgr; protein production

US6525044B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Richard E. Olson · Wilmington, US
• Thomas P. Maduskuie, Jr. · Wilmington, US
• Lorin A. Thompson, III · Higganum, US
• Andrew J. Tebben · New Hope, US
• Nenghui Wang · Guilford, US
• Wei Deng · Shanghai, CN
• Hong Liu · Seattle, US

Key dates

• Filing date: Feb 16, 2001
• Grant date: Feb 25, 2003
• Expiry date: Feb 16, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to novel carbocycles and heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.