Compounds useful as reversible inhibitors of cysteine proteases

US6525052B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Younes Bekkali · Danbury, US
• Eugene Richard Hickey · Danbury, US
• Weimin Liu · Sandy Hook, US
• Usha R. Patel · Brookfield, US
• Denice Spero · West Redding, US
• Sanxing Sun · Danbury, US
• David Thomson · Ridgefield, US
• Yancey David Ward · Sandy Hook, US
• Erick Richard Roush Young · Danbury, US

Key dates

• Filing date: Mar 14, 2001
• Grant date: Feb 25, 2003
• Expiry date: Mar 14, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.