Diaryl-enynes

US6525085B2 · kind B2 · utility

Assignee

• NPS Allelix Corp. · CA

Inventors

• Ian Egle · Mississauga, CA
• Jennifer Frey · Brampton, CA
• Methvin Isaac · Mississauga, CA

Key dates

• Filing date: Jun 17, 2002
• Grant date: Feb 25, 2003
• Expiry date: Jun 17, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided, among other things, is a compound of Formula I: wherein:Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of alkyl, alkoxy, cycloalkyl, cycloalkyloxy, heterocycloalkyl, heterocycloalkyloxy, alkanoyl, thioalkyl, aralkyl, aralkyloxy, aryloxyalkyl, aryloxyalkoxy, cycloalkyl-substituted alkyl, cycloalkyloxy-substituted alkyl, cycloalkyl-substituted alkoxy, cycloalkyloxy-substituted alkoxy, heterocycloalkyl-substituted alkyl, heterocycloalkyloxy-substituted alkyl, heterocycloalkyl-substituted alkoxy, heterocycloalkyloxy-substituted alkoxy, thioaryl, aralkylthio, thioaryl-alkyl, aralkylthioalkyl, halo, NO2, CF3, CN, OH, alkylenedioxy, SO2NRR′, NRR′, CO2R (where R and R′ are independently selected from the group consisting of H and alkyl), and a second aryl group, which may be substituted as above;R1 is selected from the group consisting of H and alkyl;R2 is selected from the group consisting of H, alkyl and benzyl;R3 is selected from the group consisting of CO2R, CONRR′, CONH(OH), COSR, SO2NRR′, PO(OR)(OR′) and tetrazolyl, wherein R and R&#8…