Microporation of tissue for delivery of bioactive agents
US6527716B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 12, 1999 |
| Grant date | Mar 4, 2003 |
| Priority date | — |
| Expiry date | Aug 12, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M37/0092
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a 20 plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.