Methods for identifying a protease inhibitor
US6528252B2 · kind B2 · utility
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55Claims
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Key dates
| Filing date | Feb 23, 2001 |
| Grant date | Mar 4, 2003 |
| Priority date | — |
| Expiry date | Feb 23, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods are disclosed whereby inhibition of proteolytic activity causes an increase in delivery of a transferable label from a viral display package to a target cell. Assaying for the transferable label in the target cell in the presence of a test substance can identify the test substance as a protease inhibitor. Protease inhibitors so identified are used therapeutically, to treat conditions such as cancer, inflammation, rheumatoid arthritis and other autoimmune diseases, and infections, including AIDS, herpes, and hepatitis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.