Thrombin inhibitors

US6528503B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Peter D. Williams · Harleysville, US
• Terry A. Lyle · Lederach, US
• Matthew Morrissette · Las Vegas, US
• Lekhanh O. Tran · West Chester, US
• Donnette D. Staas · Harleysville, US

Key dates

• Filing date: Jun 14, 2002
• Grant date: Mar 4, 2003
• Expiry date: Jun 14, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e.g. 1-(3(S)-Cyclopropyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide, and 1-(3-Cyclopropyl-3-methyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide.