Sid-polyamide fusions: a potent method of regulating gene expression
US6528620B1 · kind B1 · utility
6Cited by
1References
26Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 8, 2000 |
| Grant date | Mar 4, 2003 |
| Priority date | — |
| Expiry date | Nov 8, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/924
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to a thirteen amino acid polypeptide sequence which is able to autonomously function as a transcription repression domain through its ability to bind mSin3A. Disclosed herein are compounds and methods for regulating transcription of a selected gene. Compounds include fusions of this repression domain to a DNA-binding domain, such as a polyamide or zinc finger domain. Methods are provided for constructing and for using such compounds to regulate transcription of a selected gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.