Cyclin-selective ubiquitin carrier polypeptides

US6528633B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• Rappaport Family Institute for Research In the Medical Sciences · IL

Inventors

• Joan V. Ruderman · Wellesley, US
• Avram Hershko · Haifa, IL
• Marc W. Kirschner · Newton, US
• Fiona Townsley · Somerville, US
• Alexander Aristarkov · Boston, US
• Esther Eytan · Haifa, IL
• Hongtao Yu · Dalian, CN

Key dates

• Filing date: Jan 29, 2001
• Grant date: Mar 4, 2003
• Expiry date: Apr 14, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are novel human and clam ubiquitin carrier polypeptides involved in the ubiquitination of cyclins A and/or B. Also disclosed are inhibitors of such polypeptides, nucleic acids encoding such polypeptides and inhibitors, antibodies specific for such polypeptides, and methods of their use.