Composition and device for detecting leukocytes in urine
US6528652B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 30, 1999 |
| Grant date | Mar 4, 2003 |
| Priority date | — |
| Expiry date | Jul 30, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/948
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Thiazole esters are suitable for detecting the presence of leukocytes in urine. Such thiazole esters are suitable for use in compositions, diagnostic devices, and methods for detecting the presence of leukocytes. A thiazole ester of the invention is of the formula: or a salt or solvated salt thereof, in whichA is an N-blocked amino acid residue or N-blocked peptide chain, preferably an alanine residue or polyalanine chain; andR1 and R2 are each independently hydrogen, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkoxy, amino, unsubstituted or substituted acyl, halo, nitro, cyano, —SO3H, or hydroxy, with the proviso that R1 and R2 are not both hydrogen. In one embodiment, at least one of R1 and R2 is methoxy, ethoxy, propoxy, or butoxy. In still another embodiment, R1 is hydrogen and R2 is methoxy, ethoxy, propoxy, or butoxy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.