Process for the production of amorphous atorvastatin calcium
US6528660B1 · kind B1 · utility
21Cited by
9References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 12, 2002 |
| Grant date | Mar 4, 2003 |
| Priority date | — |
| Expiry date | Feb 12, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of amorphous atorvastatin calcium and hydrates thereof which comprises: (a) dissolving crystalline atorvastatin calcium in a non-hydroxylic solvent; (b) adding a non-polar hydrocarbon anti-solvent or adding the dissolved atorvastatin to the non-polar anti-solvent to precipitate out atorvastatin calcium; and (c) removing the solvent by filtration to afford amorphous atorvastatin calcium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.