Intermolecular multiple-quantum coherence MR imaging in humans
US6528997B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 20, 2001 |
| Grant date | Mar 4, 2003 |
| Priority date | — |
| Expiry date | Mar 20, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/56
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
In nuclear magnetic resonance imaging of the human brain or the like, multiple quantum coherences, such as intermolecular double quantum coherence (iDQC) between water molecules, are used for soft tissue contrast. A group of pulse sequences are used in which, (a) The standard &bgr;=&pgr;/2 pulse in the original CRAZED sequence is replaced with a &pgr;/3 pulse. The maximum signal derived from iDQCs is increased by a factor of 3{square root over (3)}/4. (b) The position of the acquisition window is adjusted, and a large acquisition window (small bandwidth) is used to sample a broad range of time-domain signals. (c) Receiver dynamic range is optimized. (d) A two-step phase cycle scheme for iDQC-encode gradients is designed to remove additional undesired coherence pathways.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.