Immediate release gastrointestinal drug delivery system
US6531152B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 24, 2000 |
| Grant date | Mar 11, 2003 |
| Priority date | — |
| Expiry date | Oct 24, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2866
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A gastrointestinal delivery system is provided. The system comprises a drug in combination with a swellable core material, the core being surrounded by a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble material is embedded. When the delivery device enters the gastrointestinal tract, the particulate matter takes up liquid, thus forming channels interconnecting the drug-containing core with the outside of the delivery device. Through these channels liquid enters the core which then swells to the point at which the coating is broken. When the integrity of the coating is destroyed, the core then disintegrates immediately releasing all or most of the drug at a specific site. By controlling parameters in the device, such as the core material, carrier material in the coating, and particulate matter, the location of release of the drug can be carefully controlled. Thus, the invention is also directed to a method of using the device for the treatment of disease by the release of drugs in the gastrointestinal tract in a location- and time-dependent manner.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.