Tumor antigens and CTL clones isolated by a novel procedure
US6531451B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 9, 1999 |
| Grant date | Mar 11, 2003 |
| Priority date | — |
| Expiry date | Apr 9, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for MAGE-1 and MAGE-4, respectively. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to the MAGE-1 and MAGE-4 antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.