Delivery of polynucleotides by secretory gland expression
US6531455B1 · kind B1 · utility
1Cited by
20References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 14, 2000 |
| Grant date | Mar 11, 2003 |
| Priority date | — |
| Expiry date | Apr 14, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention features methods for delivering a polypeptide to the bloodstream of a subject by introduction of a nucleic acid construct into secretory gland cells(e.g., cells of salivary gland, pancreas, or liver). In general, the method involves introduction of a nucleic acid construct into a secretory gland duct, which introduction results in expression of a gene product encoded by the introduced construct and delivery of the gene product into the bloodstream of the subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.