Gem-substituted &agr;v&bgr;3 antagonists

US6531494B1 · kind B1 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Ish Khanna · Vernon Hills, US
• Yi Yu · Skokie, US
• Balekudru Devadas · Chesterfield, US
• Hwang-Fun Lu · Ballwin, US
• Nizal Chandrakumar · North Grafton, US
• Renee Huff · Paddy Lane, US
• Bipinchandra N. Desai · Vernon Hills, US
• Srinivasan Nagarajan · Arlington Heights, US
• Alan F. Gasiecki · Vernon Hills, US
• Thomas D. Penning · Elmhurst, US
• Mark Russell · Skokie, US
• Mark Laurence Boys · Lyons, US
• Lori A. Schretzman · Gurnee, US
• Barbara Chen · Braintree, US
• Thomas E. Rogers · Ballwin, US
• John Adam Wendt · Libertyville, US
• Albert Khilevich · Glenview, US
• Yaping Wang · Cambridge, US

Key dates

• Filing date: Aug 29, 2001
• Grant date: Mar 11, 2003
• Expiry date: Aug 29, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.