Isoxazole derivatives to be used as phosphodiesterase VII inhibitors

US6531498B1 · kind B1 · utility

Assignee

• Merck Patentgesellschaft · DE

Inventors

• Hans-Michael Eggenweiler · Darmstadt, DE
• Rochus Jonas · Darmstadt, DE
• Michael Wolf · Darmstadt, DE
• Michael Gassen · Munich, DE
• Thomas Welge · Alsbach, DE

Key dates

• Filing date: May 3, 2002
• Grant date: Mar 11, 2003
• Expiry date: May 3, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of formula I and to their physiologically acceptable salts and solvates which act as phosphodiesterse VII inhibitors and are thus useful for the treatment of allergic disorders, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin disorders, inflammatory disorders, autoimmune diseases, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumor growth, tumor metastases, sepsis, memory disturbances, atherosclerosis and AIDS.