Biological materials and methods useful in the diagnosis and treatment of diseases
US6534036B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 1999 |
| Grant date | Mar 18, 2003 |
| Priority date | — |
| Expiry date | Nov 2, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method of making a &bgr;-form of a prion protein which preferably has more &bgr;-sheet than &agr;-helix structure and is soluble in the absence of a denaturant and/or is non-aggregated and exhibits partial resistance to digestion with proteinase K. The invention also relates to use of the &bgr;-form in medicine, especially for raising antibodies useful in the treatment and/or diagnosis of prion diseases. The invention also relates to methods of screening for compounds which are capable of inhibiting and/or reversing the conversion of the native &agr;-form of a prion protein to a &bgr;-form, and to uses of identified compounds in medicine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.