Pulsatile acidification wave demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby
US6534095B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 5, 2000 |
| Grant date | Mar 18, 2003 |
| Priority date | — |
| Expiry date | Sep 5, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K35/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by subjecting bone, including for example ground bone, bone cubes, chips, strips, or essentially intact bone, to a rapid high volume, pulsatile acidification wave process. The process includes subjecting bone to two or more rapid pulse/drain cycles where one or more demineralizing acids are rapidly pulsed into a vessel containing bone, and after a desired period of time, is rapidly drained from the vessel, the vessel containing the bone is then rapidly refilled with the one or more demineralizing acids (pulsed). The process allows bone to be rapidly demineralized to a precise ans specific desired residual calcium level, without sacrificing osteoinductivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.