Cyclic azapeptides with angiogenic effect

US6534478B1 · kind B1 · utility

Assignee

• Merck Patentgesellschaft · DE

Inventors

• Alfred Jonczyk · Darmstadt, DE
• Simon Goodman
• Horst Kessler · Schwalbach, DE
• Jochen Wermuth · Garching bei München, DE
• Jörg Schmitt · Hersbruck, DE

Key dates

• Filing date: Mar 23, 2000
• Grant date: Mar 18, 2003
• Expiry date: Mar 23, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula Icyclo-(aArg-aGly-aAsp-aX-aY)  Iin which aArg, aGly, aAsp, aX and aY have the meanings indicated in claim 1,and their salts,can be used as integrin inhibitors, in particular for the prophylaxis and treatment of diseases of the circulation, in thrombosis, cardiac infarct, coronary heart diseases, arteriosclerosis, in pathological processes which are supported or propagated by angiogenesis and in tumour therapy.