Synthesis of chlorophenol red glucuronic acid

US6534637B2 · kind B2 · utility

Assignee

• Beckman Coulter, Inc. · US

Inventors

• Gene Shen · Santa Clara, US
• Chan S. Oh · Chino Hills, US
• Stephanie Yancey · La Habra, US
• Craig W. Adams · Corona, US

Key dates

• Filing date: Feb 12, 2001
• Grant date: Mar 18, 2003
• Expiry date: Feb 12, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides &bgr;-D-Glucuronidase substrates of the formula: whereinR1, R2, and R7-R12 are independently selected from the group consisting of:hydrogen, fluorine, chlorine, bromine, iodine, alkyl, hydroxyl, alkoxy, carboxyl and nitro groups;R3-R6 are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, nitro and amino; andM+ is selected from the group consisting of: proton, lithium, sodium, potassium, magnesium, calcium, barium, and ammonium ion.