7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof

US6534651B2 · kind B2 · utility

Assignee

• Inotek Pharmaceuticals Corporation · US

Inventors

• Prakash Jagtap · North Andover, US
• Garry Southan · Frederick, US
• Andrew Salzman · Belmont, US
• Csaba Szabo · Gloucester, US
• Siya Ram · Winchester, US

Key dates

• Filing date: Jan 19, 2001
• Grant date: Mar 18, 2003
• Expiry date: Jan 19, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides a novel class of substituted isoindolinone derivatives, useful for the treatment of inflammation and reperfusion injuries. Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable salts, hydrates, stereoisomers or mixtures thereof are also described. The novel isoindolinone derivatives have the formula: or a pharmaceutically acceptable base or acid addition salt, hydrate, stereoisomer, or mixtures thereof, wherein R14 is described herein.